The CK1 Antibody from MyBioSource.com is a Mouse Monoclonal antibody to CK1A, CK1alpha, and CSNK1A1. This antibody recognizes Human antigen. The CK1 Antibody has been validated for the following applications: ELISA, Immunohistochemistry, and Western Blot.
Description
Background: CK1 (also designated Cytokeratin 1 or KRT1),with 644-amino acid protein (about 70kDa), is a member of the keratin family. Cytokeratins play a critical role in differentiation and tissue specialization, and they function to maintain the overall structural integrity of epithelial cells.CK1 consist of basic or neutral proteins which are arranged in pairs of heterotypic keratin chains coexpressed during differentiation of simple and stratified epithelial tissues. CK1 is specifically expressed in the spinous and granular layers of the epidermis with family member KRT10 and mutations in these genes have been associated with bullous congenital ichthyosiform erythroderma